Modern instruction sets extend their load/store-instructions with cache hints, as an additional means to bridge the processor-memory speed gap. Cache hints are used to specify the cache level at which the data is likely to be found, as well as the cache level where the data is stored after accessing it. In order to improve a program's cache behavior, the cache hint is selected based on the data locality of the instruction. We represent the data locality of an instruction by its reuse distance distribution. The reuse distance is the amount of data addressed between two accesses to the same memory location. The distribution allows to efficiently estimate the cache level where the data will be found, and to determine the level where the data should be stored to improve the hit rate. The Open64 EPIC-compiler was extended with cache hint selection and resulted in speedups of up to 36% in numerical and 23% in non-numerical programs on an Itanium multiprocessor.